NMR Stability Assay for Amyl Nitrite Ampuls

NMR Stability Assay for Amyl Nitrite Ampuls

The percentage of amyl nitrite in the contents of an amyl nitrite ampul is determined from the ratio of the area under the −CH2−ONO line to the area under the −CH3 lines in the NMR spectrum of the sample. The relative standard deviation of the method is 1.4%, and the accuracy is better than 2%....

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Veröffentlicht in:Journal of pharmaceutical sciences 1972-03, Vol.61 (3), p.428-429
Hauptverfasser: Schirmer, R.E., Zemer, R.E., Cooke, G.G.
Format: Artikel
Sprache:eng
Schlagworte:
Amyl Nitrite - analysis
amyl nitrite ampuls
Amyl nitrite ampuls-NMR stability assay
Dosage Forms
Drug Stability
Magnetic Resonance Spectroscopy
Methods
NMR spectroscopy-stability assay
NMR spectroscopy—stability assay, amyl nitrite ampuls
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Beschreibung
Zusammenfassung:The percentage of amyl nitrite in the contents of an amyl nitrite ampul is determined from the ratio of the area under the −CH2−ONO line to the area under the −CH3 lines in the NMR spectrum of the sample. The relative standard deviation of the method is 1.4%, and the accuracy is better than 2%.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600610323