Messenger RNA Structure: Compatibility of Hairpin Loops with Protein Sequence

Messenger RNA Structure: Compatibility of Hairpin Loops with Protein Sequence

Examination of the amino acid sequences of human cytochrome c and the α-chain variant of human hemoglobin Constant Spring has revealed the possibility for base-paired hairpin loops in the messenger RNA's for these proteins. A similar analysis of the bacteriophage R17 coat protein suggests an ad...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1972-03, Vol.175 (4027), p.1264-1266
Hauptverfasser: White, Harold B., Laux, Brian E., Dennis, Don
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Amino acids
Bacteriophages - analysis
Base Sequence
Capsid proteins
Computer programming
Cytochromes
Cytochromes - analysis
Genetic Code
Hemoglobins
Hemoglobins, Abnormal - analysis
Humans
Iodides
Messenger RNA
Nucleic Acid Conformation
Nucleotide sequences
Nucleotides - analysis
RNA
RNA, Messenger - analysis
Urine
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Zusammenfassung:Examination of the amino acid sequences of human cytochrome c and the α-chain variant of human hemoglobin Constant Spring has revealed the possibility for base-paired hairpin loops in the messenger RNA's for these proteins. A similar analysis of the bacteriophage R17 coat protein suggests an additional unobserved loop in the R17 RNA. If such loops are present in messenger RNA's generally, it would suggest that DNA has more than one stable base-paired conformation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.175.4027.1264