DNA polymerase from beef adrenal nuclei

A new DNA polymerase activity from adrenocortical nuclei has been observed which appears to be particulate associated. A significant degree of activity is observed in the absence of exogenous DNA template. The enzyme appears to be DNA dependent. Under the conditions of assay very little of the activ...

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Veröffentlicht in:	Biochemical and biophysical research communications 1972-02, Vol.46 (3), p.1228-1235
Hauptverfasser:	Long, George L., Garren, Leonard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Adrenal Glands - cytology Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Calcium - pharmacology Cattle Cell Nucleus - drug effects Cell Nucleus - enzymology Dactinomycin - pharmacology DNA - pharmacology DNA Nucleotidyltransferases - antagonists & inhibitors Enzyme Activation Freezing Hydrogen-Ion Concentration Hydroxymercuribenzoates - pharmacology Kinetics Magnesium - pharmacology Mercaptoethanol - pharmacology Potassium Chloride - pharmacology Thymine Nucleotides Thymus Gland Tritium Vibration
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Beschreibung
Zusammenfassung:	A new DNA polymerase activity from adrenocortical nuclei has been observed which appears to be particulate associated. A significant degree of activity is observed in the absence of exogenous DNA template. The enzyme appears to be DNA dependent. Under the conditions of assay very little of the activity is due to terminal transferase activity. This enzyme activity is different from that observed in the soluble cytoplasmic fraction.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(72)80106-2