5-Fluorouracil and Derivatives in Cancer Chemotherapy: Determination of 5-Fluorouracil in Blood

The current work describes a dialysis technique which separates 5-fluorouracil from interfering blood components and allows for subsequent GC determinations. The parameters affecting the dialysis and GC are presented. The results indicate that 5-fluorouracil is present in the free and bound states i...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1972-02, Vol.61 (2), p.301-303
Hauptverfasser:	Windheuser, J.J., Sutter, J.L., Auen, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil-dialysis separation 5-Fluorouracil—dialysis separation, GC determination from blood Chromatography, Gas Dialysis Dialysis-separation of 5-fluorouracil from blood components Dialysis—separation of 5-fluorouracil from blood components, GC determination Fluorouracil - blood Fluorouracil - therapeutic use GC determination GC determination from blood GC-determination of 5-fluorouracil in blood Humans Hydrogen-Ion Concentration Methods Neoplasms - drug therapy Solubility
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Beschreibung
Zusammenfassung:	The current work describes a dialysis technique which separates 5-fluorouracil from interfering blood components and allows for subsequent GC determinations. The parameters affecting the dialysis and GC are presented. The results indicate that 5-fluorouracil is present in the free and bound states in blood, and the method is capable of distinguishing between them.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600610243