Dissolution Rate Patterns of Log‐Normally Distributed Powders

Particles dissolving in a dissolution medium initially decrease in linear dimension, while the number of particles remains unaltered. At a particular point in time (tc) the smallest particle disappears, and from that point on the number of particles decreases. These phenomena were simulated on a dig...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1972-02, Vol.61 (2), p.223-227
Hauptverfasser:	Thurø Carstensen, J., Musa, Mahmoud N.
Format:	Artikel
Sprache:	eng
Schlagworte:	(approximate) numerical solution of log-normal distribution integrals computer simulation Computer simulations-particle dissolution Computer simulations—particle dissolution, disappearance disappearance Dissolution rates-patterns of log-normally dis-tributed powders dissolution under sink conditions-rate patterns Kinetics log-normal distribution Mathematics Models, Theoretical Particle dissolution Particle dissolution, sink conditions—powder, log‐normal distribution, rate patterns, computer simulation Powders Powders, dissolution under sink conditions—rate patterns, (approximate) numerical solution of log‐normal distribution integrals rate patterns sink conditions-powder Solubility Time Factors
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Beschreibung
Zusammenfassung:	Particles dissolving in a dissolution medium initially decrease in linear dimension, while the number of particles remains unaltered. At a particular point in time (tc) the smallest particle disappears, and from that point on the number of particles decreases. These phenomena were simulated on a digital computer, and the agglomerate dissolution pattern under sink conditions was shown to follow a cube root law, but the slopes differ according to whether ttc.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600610217