IDENTIFICATION OF COMPONENTS IN THE BLEOMYCIN COMPLEX BY DIRECT TLC/FABMS

A fast method is described for obtaining mass spectral identifications of components of the bleomycin complex by a new thin-layer chromatography/fast atom bombardment mass spectrometry (TLC/FABMS) procedure. This method provides rapid analyses of antibiotics in mixtures and the bleomycins represent...

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Veröffentlicht in:	Journal of antibiotics 1984, Vol.37(9), pp.1098-1100
Hauptverfasser:	CHANG, TED T., LEE, TAIKWANG M., BORDERS, DONALD B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bleomycin - analysis Chromatography, Thin Layer General pharmacology Mass Spectrometry Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Streptomyces verticillus
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Beschreibung
Zusammenfassung:	A fast method is described for obtaining mass spectral identifications of components of the bleomycin complex by a new thin-layer chromatography/fast atom bombardment mass spectrometry (TLC/FABMS) procedure. This method provides rapid analyses of antibiotics in mixtures and the bleomycins represent a difficult example since they are very polar, high molecular weight and thermally unstable compounds.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.37.1098