Does the complex of aminoacyl-tRNA synthetases and tRNA-modifying enzymes prevent miscoding?

Several aminoacyl-tRNA synthetases of higher eukaryotes have always been found as multienzyme complexes. There are indications that these complexes can be associated with some tRNA-modifying enzymes. The function of such complexes is unclear. I have noticed that 6 out of 7 aminoacyl-tRNA synthetases...

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Veröffentlicht in:	FEBS letters 1984-12, Vol.178 (1), p.6-9
1. Verfasser:	Ryazanov, A.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - genetics Amino Acyl-tRNA Synthetases - metabolism Aminoacyl-tRNA synthetase Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetic Code Miscoding Models, Genetic Molecular and cellular biology Molecular genetics Multienzyme complex Multienzyme Complexes - metabolism Translation. Translation factors. Protein processing tRNA modification Wobble position
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Zusammenfassung:	Several aminoacyl-tRNA synthetases of higher eukaryotes have always been found as multienzyme complexes. There are indications that these complexes can be associated with some tRNA-modifying enzymes. The function of such complexes is unclear. I have noticed that 6 out of 7 aminoacyl-tRNA synthetases most commonly occurring in complexes correspond to a group of tRNAs which must always contain a modified U in the first position of their anticodons. A hypothesis is proposed according to which association of 6 aminoacyl-tRNA synthetases with U-modifying enzymes can protect a cell from miscoding.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(84)81228-4