Insulin-stimulating protein from human plasma

An insulin-stimulating protein was isolated from human plasma by a procedure involving Sephadex G-100 chromatography and reverse-phase HPLC. The isolated material gave a single band on SDS-polyacrylamide gel electrophoresis. This protein itself had no insulin-like activity, but enhanced fatty acid s...

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Veröffentlicht in:	FEBS letters 1984-11, Vol.177 (2), p.217-220
Hauptverfasser:	Arakaki, Naokatu, Oribe, Toshiya, Ueno, Akemichi, Inoue, Hideo, Takeda, Yoshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocyte Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Biological and medical sciences Blood Proteins - isolation & purification Blood Proteins - pharmacology Chromatography, Gel Chromatography, High Pressure Liquid CO 2 production CO2 production Electrophoresis, Polyacrylamide Gel Endocrine pancreas Fatty acid synthesis Fatty Acids - biosynthesis Fundamental and applied biological sciences. Psychology H-ISP Hormones. Régulation Humans Insulin Insulin - metabolism Insulin - pharmacology Insulin stimulation insulin-stimulating protein from human plasma Kinetics Male man plasma Rats Rats, Inbred Strains somatomedins Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	An insulin-stimulating protein was isolated from human plasma by a procedure involving Sephadex G-100 chromatography and reverse-phase HPLC. The isolated material gave a single band on SDS-polyacrylamide gel electrophoresis. This protein itself had no insulin-like activity, but enhanced fatty acid synthesis from glucose in rat adipose tissue explants in the presence of suboptimal concentrations of insulin. It also stimulated the effect of insulin on CO 2 liberation from glucose by isolated rat adipocytes and increased the maximal response to insulin.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(84)81286-7