Dopaminergic activity is reduced in diabetic rats

Dopamine synthesis rates in synaptosomes prepared from the striata of alloxan-diabetic rats were considerably lower than in control preparations. Striatal dopamine metabolite levels, after an initial increase, were also reduced at 3 and 6 weeks after alloxan administration. These findings suggest th...

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Veröffentlicht in:	Neuroscience letters 1984-08, Vol.49 (3), p.301-306
1. Verfasser:	Saller, C.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - analysis Alloxan Animals Biological and medical sciences Corpus Striatum - analysis Corpus Striatum - metabolism diabetes Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Dopamine - analysis Dopamine - biosynthesis dopamine metabolites dopamine synthesis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Homovanillic Acid - analysis Male Medical sciences rat Rats Rats, Inbred Strains Synaptosomes - metabolism
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Zusammenfassung:	Dopamine synthesis rates in synaptosomes prepared from the striata of alloxan-diabetic rats were considerably lower than in control preparations. Striatal dopamine metabolite levels, after an initial increase, were also reduced at 3 and 6 weeks after alloxan administration. These findings suggest that dopaminergic functioning may be impaired in diabetic rats.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(84)90306-9