Effect of microelectrophoretically applied corticosterone on raphe neurones in the rat

The effect of microelectrophoretic application of corticosterone (CS) on single neurones of raphe nuclei (RN) were investigated in rats under urethane anaesthesia. Ejecting currents generally ranged from 5 to 40 nA. CS produced an excitatory effect in 61% and no effect in 39% of the neurones. None o...

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Veröffentlicht in:	Neuroscience letters 1984-09, Vol.50 (1), p.307-311
Hauptverfasser:	Avañzino, G.L., Ermirio, R., Ruggeri, P., Cogo, C.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adrenocorticotropic Hormone - metabolism Animals Biochemistry and metabolism Biological and medical sciences brainstem Central nervous system corticosterone Corticosterone - pharmacology Fundamental and applied biological sciences. Psychology glucocorticoid hormones Hypothalamus - physiology Iontophoresis Male microelectrophoresis Neural Pathways - physiology Pain - physiopathology raphe nuclei Raphe Nuclei - drug effects Raphe Nuclei - physiology rat Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs
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Zusammenfassung:	The effect of microelectrophoretic application of corticosterone (CS) on single neurones of raphe nuclei (RN) were investigated in rats under urethane anaesthesia. Ejecting currents generally ranged from 5 to 40 nA. CS produced an excitatory effect in 61% and no effect in 39% of the neurones. None of the 54 neurones studied was inhibited by CS. These quite homogeneous data support the hypothesis that RN are involved in the regulation of most of the nervous functions in which glucocorticoid hormones have been implicated.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(84)90504-4