A Major Human Histone Gene Cluster on the Long Arm of Chromosome 1

A Major Human Histone Gene Cluster on the Long Arm of Chromosome 1

A human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with $^{32}$P-labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confir...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1984-11, Vol.226 (4676), p.838-840
Hauptverfasser: Green, L., Van Antwerpen, R., Stein, J., Stein, G., Tripputi, P., Emanuel, B., Selden, J., Croce, C.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Animals
Biological and medical sciences
Cell lines
Chromosome Mapping
Chromosomes
Chromosomes, Human, 1-3
Chromosomes, Human, 6-12 and X
Cloning
DNA
DNA - metabolism
DNA probes
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Genetic research
Genomics
Histones
Histones - genetics
Human chromosomes
Humans
Hybrid cells
Hybrid Cells - metabolism
Mice
Molecular and cellular biology
Molecular genetics
Multigene family
Nucleic Acid Hybridization
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Zusammenfassung:A human histone gene cluster was assigned to chromosome 1 by Southern blot analysis of DNA's from a series of mouse-human somatic cell hybrids with $^{32}$P-labeled cloned human H4 and H3 histone DNA as probes. Localization of this histone gene cluster on the long arm of chromosome 1 was confirmed by in situ hybridization of this DNA probe to metaphase chromosomes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6494913