Electrical and Mechanical Events through Activation of Muscarinic Receptor in the Smooth Muscle of Guinea-pig Vas Deferens
Electrical and mechanical responses of the guinea-pig vas deferens to exogenous acetylcholine (ACh) were observed by means of a single sucrose-gap method. ACh at various concentrations evoked a contraction consisting of two components. The initial component seemed to be independent of a depolarizati...
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Veröffentlicht in: | Japanese journal of physiology 1984, Vol.34(3), pp.557-560 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Electrical and mechanical responses of the guinea-pig vas deferens to exogenous acetylcholine (ACh) were observed by means of a single sucrose-gap method. ACh at various concentrations evoked a contraction consisting of two components. The initial component seemed to be independent of a depolarization, while the second one was dependent on it. All ACh responses were abolished by Ca removal from the external solution. The results suggest the existence of a pathway by which ACh even at low concentrations causes a Ca influx without potential changes. |
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ISSN: | 0021-521X 1881-1396 |
DOI: | 10.2170/jjphysiol.34.557 |