Crystalline Cholera Toxin and Toxoid

The exo-enterotoxin of Vibrio cholerae has been obtained in crystalline form. A solution of the crystalline protein was equal in potency to the parent pure toxin in both choleragenicity and skin reactivity. Crystals of the natural toxoid, choleragenoid, resemble those of the toxin in appearance. A s...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1972-02, Vol.175 (4021), p.529-530
Hauptverfasser:	Finkelstein, Richard A., LoSpalluto, Joseph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cholera Chromatography Crystallization Crystals Dermis Dosage Electrophoresis, Disc Enterotoxins - administration & dosage Enterotoxins - isolation & purification Flocculation Tests Lipids Microscopy Rabbits Reactivity Skin Skin Tests Solubility Toxins Toxoids - administration & dosage Toxoids - isolation & purification Vibrio - analysis
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Beschreibung
Zusammenfassung:	The exo-enterotoxin of Vibrio cholerae has been obtained in crystalline form. A solution of the crystalline protein was equal in potency to the parent pure toxin in both choleragenicity and skin reactivity. Crystals of the natural toxoid, choleragenoid, resemble those of the toxin in appearance. A solution of crystalline choleragenoid was equivalent to the parent preparation in the flocculation test.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.175.4021.529