Inexact three-dimensional reconstruction of a biological macromolecule from a restricted number of projections

Inexact three-dimensional reconstruction of a biological macromolecule from a restricted number of projections

A computer-generated three-dimensional model of Lumbricus terrestris hemoglobin has been obtained by reconstruction from four STEM low-dose computer-averaged micrographs. X-ray projections of a wooden model constructed from the calculated two-dimensional sections through the molecule were generally...

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Veröffentlicht in:Ultramicroscopy 1984, Vol.13 (4), p.365-371
Hauptverfasser: Crewe, A.V., Crewe, D.A., Kapp, O.H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Annelida - analysis
Computers
Hemoglobins
Methods
Models, Molecular
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Zusammenfassung:A computer-generated three-dimensional model of Lumbricus terrestris hemoglobin has been obtained by reconstruction from four STEM low-dose computer-averaged micrographs. X-ray projections of a wooden model constructed from the calculated two-dimensional sections through the molecule were generally consistent with the original STEM projections of the hemoglobin and suggest the presence of large gaps between the central regions of adjacent 1/12th subunits of opposite tiers.
ISSN:0304-3991
1879-2723
DOI:10.1016/0304-3991(84)90002-0