Thrombin-induced degranulation of cultured bone marrow-derived mast cells

This study was undertaken to determine if a plasma protease such as thrombin, a highly specific procoagulant enzyme that has numerous effects on platelets, endothelial cells, and smooth muscle cells, could mediate mast cell activation processes. Our results indicate that at near physiologic levels,...

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Veröffentlicht in:	The Journal of immunology (1950) 1984-12, Vol.133 (6), p.3282-3285
Hauptverfasser:	Razin, E, Marx, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombin III - pharmacology beta-N-Acetylhexosaminidases Biological and medical sciences Bone Marrow Cells Cattle Cells, Cultured Cytoplasmic Granules - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Hexosaminidases - metabolism Hirudins - pharmacology Histamine Release Humans Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunobiology Mast Cells - metabolism Mice Reaction mechanisms, antibodies, chemical mediators Substrate Specificity Thrombin - antagonists & inhibitors Thrombin - pharmacology
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Beschreibung
Zusammenfassung:	This study was undertaken to determine if a plasma protease such as thrombin, a highly specific procoagulant enzyme that has numerous effects on platelets, endothelial cells, and smooth muscle cells, could mediate mast cell activation processes. Our results indicate that at near physiologic levels, thrombin can rapidly trigger mast cell degranulation without activating the 5-lipoxygenase system.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.133.6.3282