Topical Hydroxyurea and Psoriasis

Hydroxyurea, as a 10% cream, produces a significant involutionary effect on psoriatic plaques when used under continuous plastic film occlusion. When used with only partial occlusion, however, the effect is only slightly better than that of the base alone. Further studies with the use of metabolical...

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Veröffentlicht in:	Journal of investigative dermatology 1972-01, Vol.58 (1), p.24-27
Hauptverfasser:	Zackheim, Herschel S., Karasek, Marvin A., Cox, Alvin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Clinical Trials as Topic Female Humans Hydroxyurea - administration & dosage Keratosis - pathology Male Mitosis Plastics Psoriasis - drug therapy Psoriasis - pathology Skin - pathology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Hydroxyurea, as a 10% cream, produces a significant involutionary effect on psoriatic plaques when used under continuous plastic film occlusion. When used with only partial occlusion, however, the effect is only slightly better than that of the base alone. Further studies with the use of metabolically active derivatives of hydroxyurea and/or different vehicles are warranted.
ISSN:	0022-202X 1523-1747
DOI:	10.1111/1523-1747.ep13077204