The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics
Benzimidazole anthelmintics may act by interfering with the microtubule system in Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [ 3H]colchicine. In addition, t...
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| Veröffentlicht in: | Biochemical pharmacology 1984-10, Vol.33 (19), p.3037-3040 |
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| container_end_page | 3040 |
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| container_title | Biochemical pharmacology |
| container_volume | 33 |
| creator | Barrowman, Margaret M. Marriner, Susan E. Bogan, James A. |
| description | Benzimidazole anthelmintics may act by interfering with the microtubule system in
Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to
A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [
3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules
in vitro. |
| doi_str_mv | 10.1016/0006-2952(84)90605-1 |
| format | Article |
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Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to
A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [
3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules
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Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to
A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [
3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules
in vitro.</description><subject>Animals</subject><subject>Anthelmintics - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Ascaris - metabolism</subject><subject>Benzimidazoles - metabolism</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Colchicine - metabolism</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymers - metabolism</subject><subject>Sulfhydryl Compounds - pharmacology</subject><subject>Tubulin - metabolism</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoModVv9Bwq5EGkvRpPZTCZzI5RiVSh4U69DPs64R2aSNckUdn-92e6yl16FvOc5L8lDyDvOPnHG5WfGmGzaoWuvlbgZmGRdw1-QFVf9usZSvSSrM_KaXOb853BVkl-QCykq1YkV2T1ugFoMHsNvaoKnebEZ_i4QCsWwQYsFY6BxpGWxy4SBbuO0myHh3jxPanKbnUmY6-oy0-saPGFJ8YbaHbUQ9jijN_s4Qe0vG5hmDAVdfkNejWbK8PZ0XpFf918f7743Dz-__bi7fWjcWsnSGMs749dg2wF8y0SvGOv80HYCHHOSSTsykN0olWLeOQ6m516ZbvASvOmH9RX5eOzdplj_lYueMTuYJhMgLlkr3qpeClZBcQRdijknGPU24WzSTnOmD8b1wZ8-6NRK6Gfjmte196f-xc7gz0snxXX-4TQ31dM0JhMc5jM2sKFnQlbsyxGD6uIJIensEIIDjwlc0T7i_9_xDz16nz0</recordid><startdate>19841001</startdate><enddate>19841001</enddate><creator>Barrowman, Margaret M.</creator><creator>Marriner, Susan E.</creator><creator>Bogan, James A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19841001</creationdate><title>The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics</title><author>Barrowman, Margaret M. ; Marriner, Susan E. ; Bogan, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ab15ad3eb29ed20478005d9254ec0c606bf0e65f6880dcc1ea71d8a59d6eda793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Anthelmintics - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Ascaris - metabolism</topic><topic>Benzimidazoles - metabolism</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Colchicine - metabolism</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymers - metabolism</topic><topic>Sulfhydryl Compounds - pharmacology</topic><topic>Tubulin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrowman, Margaret M.</creatorcontrib><creatorcontrib>Marriner, Susan E.</creatorcontrib><creatorcontrib>Bogan, James A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrowman, Margaret M.</au><au>Marriner, Susan E.</au><au>Bogan, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1984-10-01</date><risdate>1984</risdate><volume>33</volume><issue>19</issue><spage>3037</spage><epage>3040</epage><pages>3037-3040</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>Benzimidazole anthelmintics may act by interfering with the microtubule system in
Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to
A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [
3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules
in vitro.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6487354</pmid><doi>10.1016/0006-2952(84)90605-1</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1984-10, Vol.33 (19), p.3037-3040 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anthelmintics - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Ascaris - metabolism Benzimidazoles - metabolism Benzimidazoles - pharmacology Biological and medical sciences Colchicine - metabolism In Vitro Techniques Medical sciences Pharmacology. Drug treatments Polymers - metabolism Sulfhydryl Compounds - pharmacology Tubulin - metabolism |
| title | The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics |
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