The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics

Benzimidazole anthelmintics may act by interfering with the microtubule system in Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [ 3H]colchicine. In addition, t...

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Veröffentlicht in:	Biochemical pharmacology 1984-10, Vol.33 (19), p.3037-3040
Hauptverfasser:	Barrowman, Margaret M., Marriner, Susan E., Bogan, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Ascaris - metabolism Benzimidazoles - metabolism Benzimidazoles - pharmacology Biological and medical sciences Colchicine - metabolism In Vitro Techniques Medical sciences Pharmacology. Drug treatments Polymers - metabolism Sulfhydryl Compounds - pharmacology Tubulin - metabolism
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Zusammenfassung:	Benzimidazole anthelmintics may act by interfering with the microtubule system in Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [ 3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules in vitro.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(84)90605-1