A new suppressor of mutations in the DNA repair-recombination genes of bacteriophage T4: sur
A new mutation designated sur was isolated as a suppressor of a mutation in the uvsX gene of T4 phage. Unlike the other suppressors of mutations in genes involved in DNA repair and recombination, sur has a wide range, suppressing both DNA repair and replication defects in mutations in genes uvsX, uv...
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Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1984-09, Vol.137 (2), p.331-337 |
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Sprache: | eng |
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Zusammenfassung: | A new mutation designated
sur was isolated as a suppressor of a mutation in the
uvsX gene of T4 phage. Unlike the other suppressors of mutations in genes involved in DNA repair and recombination,
sur has a wide range, suppressing both DNA repair and replication defects in mutations in genes
uvsX,
uvsY, 46, 47, and 59. However, its suppressor functions may be confined to the
uvsX-
uvsY DNA repair pathway since
sur did not suppress a mutation in the
denV gene. The
sur mutation results in an increased degradation of host DNA to an acid-soluble form, but this increase was blocked by a mutation in gene 46 (nuclease) indicating that the
sur function is involved in an earlier step in the degradation of host DNA. This increased degradation of host DNA might be a reflection of a compensatory increase in an alternate DNA repair activity in the [
sur] mutant. |
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ISSN: | 0042-6822 1096-0341 |
DOI: | 10.1016/0042-6822(84)90225-3 |