Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol
Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first da...
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| Veröffentlicht in: | Life sciences (1973) 1984-10, Vol.35 (17), p.1725-1730 |
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| container_title | Life sciences (1973) |
| container_volume | 35 |
| creator | Field, Elizabeth Tyrey, Lee |
| description | Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first day of full vaginal cornification delayed the onset of estrus and the occurrence of the first ovulation by an average of 4.3 ± 0.9 (S.E.M.) days in comparison with pair-fed, vehicle-treated animals (p |
| doi_str_mv | 10.1016/0024-3205(84)90268-6 |
| format | Article |
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Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first day of full vaginal cornification delayed the onset of estrus and the occurrence of the first ovulation by an average of 4.3 ± 0.9 (S.E.M.) days in comparison with pair-fed, vehicle-treated animals (p<0.001). Ovulation during the first estrus occurred in 92% of the animals in each treatment group without a difference in the average number of ova ovulated. The delayed sexual maturation in animals treated with THC could not be attributed to reduced body weight gain since body weights in THC- and vehicle-treated groups were equivalent when vehicle-treated animals came into estrus. Delayed ovulation in THC-treated animals did not merely reflect the repeated blockage of ovulation from otherwise competent follicles in that the onset of vaginal cornification was delayed to a comparable extent. Rather, the data suggest retarded development of ovarian follicles, possibly as a result of pituitary suppression. It is noteworthy that, although delayed, both vaginal cornification and ovulation occured in spite of continued THC treatment, suggesting the development of drug tolerance.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(84)90268-6</identifier><identifier>PMID: 6090846</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Dronabinol - pharmacology ; Drug addictions ; Drug Tolerance ; Estrus ; Female ; Medical sciences ; Pregnancy ; Rats ; Sexual Maturation - drug effects ; Time Factors ; Toxicology</subject><ispartof>Life sciences (1973), 1984-10, Vol.35 (17), p.1725-1730</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-dd8c2362fa1ce0c877fd79b60b2f7ca7fae1dfbe6480771156fc599b39ddeb023</citedby><cites>FETCH-LOGICAL-c386t-dd8c2362fa1ce0c877fd79b60b2f7ca7fae1dfbe6480771156fc599b39ddeb023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(84)90268-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9217569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6090846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Field, Elizabeth</creatorcontrib><creatorcontrib>Tyrey, Lee</creatorcontrib><title>Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first day of full vaginal cornification delayed the onset of estrus and the occurrence of the first ovulation by an average of 4.3 ± 0.9 (S.E.M.) days in comparison with pair-fed, vehicle-treated animals (p<0.001). Ovulation during the first estrus occurred in 92% of the animals in each treatment group without a difference in the average number of ova ovulated. The delayed sexual maturation in animals treated with THC could not be attributed to reduced body weight gain since body weights in THC- and vehicle-treated groups were equivalent when vehicle-treated animals came into estrus. Delayed ovulation in THC-treated animals did not merely reflect the repeated blockage of ovulation from otherwise competent follicles in that the onset of vaginal cornification was delayed to a comparable extent. Rather, the data suggest retarded development of ovarian follicles, possibly as a result of pituitary suppression. It is noteworthy that, although delayed, both vaginal cornification and ovulation occured in spite of continued THC treatment, suggesting the development of drug tolerance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Dronabinol - pharmacology</subject><subject>Drug addictions</subject><subject>Drug Tolerance</subject><subject>Estrus</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Sexual Maturation - drug effects</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoO4rOPqP1DIQUQPrUm6Ox-XBVl1V1jwoueQTipOJJ2MSXrZ-ff2OMMcPRVUPe9L8SD0ipIPlFD-kRA2dD0j4zs5vFeEcdnxJ2hDpVAd4T19ijZn5Bl6XutvQsg4iv4SXXKiiBz4BtnPEM0eHK7wuJiIZ9OWYlrICYeE2xawh9lEwOsSu6WE9AvbbckpWAyPu1yXArhl7CA206muQStmu3clW5OSmULK8QW68CZWeHmaV-jn1y8_bu66---3324-3Xe2l7x1zknLes68oRaIlUJ4J9TEycS8sEZ4A9T5CfggiRCUjtzbUampV87BRFh_hd4ee3cl_1mgNj2HaiFGkyAvVUvKhJJsXMHhCNqSay3g9a6E2ZS9pkQf3OqDOH0Qp-Wg_7nVfI29PvUv0wzuHDrJXO9vTndTrYm-mGRDPWOKUTFytWLXRwxWFw8Biq42QLLgQgHbtMvh_3_8BZmNlyI</recordid><startdate>19841022</startdate><enddate>19841022</enddate><creator>Field, Elizabeth</creator><creator>Tyrey, Lee</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19841022</creationdate><title>Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol</title><author>Field, Elizabeth ; Tyrey, Lee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-dd8c2362fa1ce0c877fd79b60b2f7ca7fae1dfbe6480771156fc599b39ddeb023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Dronabinol - pharmacology</topic><topic>Drug addictions</topic><topic>Drug Tolerance</topic><topic>Estrus</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Sexual Maturation - drug effects</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Field, Elizabeth</creatorcontrib><creatorcontrib>Tyrey, Lee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Field, Elizabeth</au><au>Tyrey, Lee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1984-10-22</date><risdate>1984</risdate><volume>35</volume><issue>17</issue><spage>1725</spage><epage>1730</epage><pages>1725-1730</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first day of full vaginal cornification delayed the onset of estrus and the occurrence of the first ovulation by an average of 4.3 ± 0.9 (S.E.M.) days in comparison with pair-fed, vehicle-treated animals (p<0.001). Ovulation during the first estrus occurred in 92% of the animals in each treatment group without a difference in the average number of ova ovulated. The delayed sexual maturation in animals treated with THC could not be attributed to reduced body weight gain since body weights in THC- and vehicle-treated groups were equivalent when vehicle-treated animals came into estrus. Delayed ovulation in THC-treated animals did not merely reflect the repeated blockage of ovulation from otherwise competent follicles in that the onset of vaginal cornification was delayed to a comparable extent. Rather, the data suggest retarded development of ovarian follicles, possibly as a result of pituitary suppression. It is noteworthy that, although delayed, both vaginal cornification and ovulation occured in spite of continued THC treatment, suggesting the development of drug tolerance.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6090846</pmid><doi>10.1016/0024-3205(84)90268-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1984-10, Vol.35 (17), p.1725-1730 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Body Weight Dronabinol - pharmacology Drug addictions Drug Tolerance Estrus Female Medical sciences Pregnancy Rats Sexual Maturation - drug effects Time Factors Toxicology |
| title | Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol |
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