Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol

Delayed sexual maturation in the female rat during chronic exposure to delta-9-tetrahydrocannabinol

Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first da...

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Veröffentlicht in:Life sciences (1973) 1984-10, Vol.35 (17), p.1725-1730
Hauptverfasser: Field, Elizabeth, Tyrey, Lee
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Body Weight
Dronabinol - pharmacology
Drug addictions
Drug Tolerance
Estrus
Female
Medical sciences
Pregnancy
Rats
Sexual Maturation - drug effects
Time Factors
Toxicology
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Zusammenfassung:Δ-9-tetrahydrocannabinol (THC), the major psychoactive component of marihuana, retarded sexual maturation in the pubertal female rat as indicated by a delayed appearance of estrus and ovulation. Twice daily intraperitoneal injections of 10 mg THC/kg body weight from 27 days of age until the first day of full vaginal cornification delayed the onset of estrus and the occurrence of the first ovulation by an average of 4.3 ± 0.9 (S.E.M.) days in comparison with pair-fed, vehicle-treated animals (p
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(84)90268-6