Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease

The effect of prior incubation with a single concentration of isoproterenol (10 −4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups pri...

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Veröffentlicht in:Life sciences (1973) 1984-10, Vol.35 (17), p.1795-1802
Hauptverfasser: Oppenheim, Gerald, Mintzer, Jacob, Halperin, Yitzhak, Eliakim, Rami, Stessman, Jochanan, Ebstein, Richard P.
Format: Artikel
Sprache:eng
Schlagworte:
Adenylyl Cyclases - blood
Adult
Aged
Aging
Alzheimer Disease - enzymology
Biological and medical sciences
Cyclic AMP - blood
Female
General aspects
Humans
In Vitro Techniques
Isoproterenol - pharmacology
Lymphocytes - enzymology
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Prostaglandins E - blood
Receptors, Adrenergic, beta - blood
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Zusammenfassung:The effect of prior incubation with a single concentration of isoproterenol (10 −4 M) for 2 hours at 37°C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subject groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(84)90277-7