Properties of asialo and aglycoprothrombin

Native bovine prothrombin was shown to have a circulatory half-life of 90 minutes when injected into the circulatory system of rats. Removal of sialic acid resulted in a circulatory half-life of only 9 minutes and further enzymatic degradation of the carbohydrate restored the circulatory half-life t...

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Veröffentlicht in:	Biochemical and biophysical research communications 1971-10, Vol.45 (1), p.198-203
Hauptverfasser:	Nelsestuen, G.L., Suttie, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Animals Cattle Chemical Phenomena Chemistry Endopeptidases Galactosidases Glucosamine Glycopeptides - blood Glycopeptides - isolation & purification Glycoside Hydrolases Half-Life Hydrolysis Kinetics Male Mannose Neuraminic Acids - physiology Neuraminidase Plants - enzymology Prothrombin - metabolism Rats
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Beschreibung
Zusammenfassung:	Native bovine prothrombin was shown to have a circulatory half-life of 90 minutes when injected into the circulatory system of rats. Removal of sialic acid resulted in a circulatory half-life of only 9 minutes and further enzymatic degradation of the carbohydrate restored the circulatory half-life to more nearly that of intact prothrombin. These observations broaden the generality of this phenomenon displayed by some other glycoproteins and therefore the possibility that sialic acid may function in determining the circulatory life of glycoproteins.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(71)90069-6