Degradation of I 125-labelled serum low density lipoprotein in normal and estrogen-treated male rats

Experiments were performed to determine the site of degradation of radioiodinated serum low density lipoprotein (I 125-LDL). Estrogen treatment, which was found to result in near absence of LDL in adult male rats, was employed for comparison with the normal catabolic system. Differences were noted b...

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Veröffentlicht in:	Biochemical and biophysical research communications 1971-09, Vol.44 (6), p.1471-1477
Hauptverfasser:	Hay, R.V., Pottenger, L.A., Reingold, A.L., Getz, G.S., Wissler, R.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Animals Benzoates - pharmacology Blood Proteins - isolation & purification Blood Proteins - metabolism Duodenum - metabolism Electrophoresis Epididymis - metabolism Estradiol - pharmacology Ileum - metabolism Iodine Isotopes Kidney - metabolism Kinetics Lipoproteins - blood Lipoproteins - isolation & purification Lipoproteins - metabolism Liver - drug effects Liver - metabolism Lung - metabolism Male Perfusion Rats Spleen - metabolism
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Beschreibung
Zusammenfassung:	Experiments were performed to determine the site of degradation of radioiodinated serum low density lipoprotein (I 125-LDL). Estrogen treatment, which was found to result in near absence of LDL in adult male rats, was employed for comparison with the normal catabolic system. Differences were noted between normal and estrogen-treated rats regarding kinetics of disappearance of I 125-LDL from the serum. In situ perfused livers from normal rats were found to take up and degrade I 125-LDL; both processes were accelerated in perfused livers from estrogen-treated rats. The liver is proposed as a major site of I 125-LDL uptake and degradation.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(71)80251-6