Parkinson's disease: depletion of substantia nigra neurotensin receptors
Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These res...
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| Veröffentlicht in: | Brain research 1984-08, Vol.308 (1), p.186-190 |
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| container_end_page | 190 |
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| container_start_page | 186 |
| container_title | Brain research |
| container_volume | 308 |
| creator | Uhl, G.R. Whitehouse, P.J. Price, D.L. Tourtelotte, W.W. Kuhar, M.J. |
| description | Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits. |
| doi_str_mv | 10.1016/0006-8993(84)90935-1 |
| format | Article |
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In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>diseases</subject><subject>Humans</subject><subject>Kinetics</subject><subject>man</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>neurotensin</subject><subject>Neurotensin - metabolism</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson's disease</subject><subject>peptide</subject><subject>receptor autoradiography</subject><subject>Receptors, Neurotensin</subject><subject>Receptors, Neurotransmitter - metabolism</subject><subject>Reference Values</subject><subject>substantia nigra</subject><subject>Substantia Nigra - metabolism</subject><subject>Tritium</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vFDEMQKOKqiyl_6BIc0CUHgaSSSYfPSBVFbSVKpUDnKMk46kCs8kSz1Ti35NlV3uEiy3bz5b1CDln9AOjTH6klMpWG8Pfa3FpqOF9y47IimnVtbIT9AVZHZCX5BXij1pybugJOZG0dnu-IndfXfkZE-Z0gc0QERzCVTPAZoI55tTkscHF4-zSHF2T4lOpEZaSZ0gYU1MgwGbOBV-T49FNCGf7fEq-f_n87eaufXi8vb-5fmiDYGpunVJ9GHzntPQOoNM8dFwZwUcvlRSd9oYPPdeeKxCjH4E5rT2AEJ2RWgV-St7t7m5K_rUAznYdMcA0uQR5QatZJ4yk8r8gE5SbXuoKih0YSkYsMNpNiWtXfltG7da03Wq0W41WC_vXtGV17c3-_uLXMByW9mrr_O1-7jC4aSwuhYgHTGtFte4r9mmHQZX2HKFYDBFSgCFWt7Mdcvz3H38AqWyaLw</recordid><startdate>19840806</startdate><enddate>19840806</enddate><creator>Uhl, G.R.</creator><creator>Whitehouse, P.J.</creator><creator>Price, D.L.</creator><creator>Tourtelotte, W.W.</creator><creator>Kuhar, M.J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19840806</creationdate><title>Parkinson's disease: depletion of substantia nigra neurotensin receptors</title><author>Uhl, G.R. ; Whitehouse, P.J. ; Price, D.L. ; Tourtelotte, W.W. ; Kuhar, M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a775cdb2a86baee283c237943fb676428b93d538b37e4fbfe1a88bee4429687c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>diseases</topic><topic>Humans</topic><topic>Kinetics</topic><topic>man</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>neurotensin</topic><topic>Neurotensin - metabolism</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson's disease</topic><topic>peptide</topic><topic>receptor autoradiography</topic><topic>Receptors, Neurotensin</topic><topic>Receptors, Neurotransmitter - metabolism</topic><topic>Reference Values</topic><topic>substantia nigra</topic><topic>Substantia Nigra - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uhl, G.R.</creatorcontrib><creatorcontrib>Whitehouse, P.J.</creatorcontrib><creatorcontrib>Price, D.L.</creatorcontrib><creatorcontrib>Tourtelotte, W.W.</creatorcontrib><creatorcontrib>Kuhar, M.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uhl, G.R.</au><au>Whitehouse, P.J.</au><au>Price, D.L.</au><au>Tourtelotte, W.W.</au><au>Kuhar, M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parkinson's disease: depletion of substantia nigra neurotensin receptors</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-08-06</date><risdate>1984</risdate><volume>308</volume><issue>1</issue><spage>186</spage><epage>190</epage><pages>186-190</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. 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| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Age Factors Aged Autoradiography Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases diseases Humans Kinetics man Medical sciences Middle Aged Neurology neurotensin Neurotensin - metabolism Parkinson Disease - metabolism Parkinson's disease peptide receptor autoradiography Receptors, Neurotensin Receptors, Neurotransmitter - metabolism Reference Values substantia nigra Substantia Nigra - metabolism Tritium |
| title | Parkinson's disease: depletion of substantia nigra neurotensin receptors |
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