Parkinson's disease: depletion of substantia nigra neurotensin receptors

Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These res...

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Veröffentlicht in:	Brain research 1984-08, Vol.308 (1), p.186-190
Hauptverfasser:	Uhl, G.R., Whitehouse, P.J., Price, D.L., Tourtelotte, W.W., Kuhar, M.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Autoradiography Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases diseases Humans Kinetics man Medical sciences Middle Aged Neurology neurotensin Neurotensin - metabolism Parkinson Disease - metabolism Parkinson's disease peptide receptor autoradiography Receptors, Neurotensin Receptors, Neurotransmitter - metabolism Reference Values substantia nigra Substantia Nigra - metabolism Tritium
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Zusammenfassung:	Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. ‘Saturation’ analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(84)90935-1