Correlation of differentiation state and silver staining of nucleolar organizers in the promyelocytic leukemia cell line HL-60

We have applied nucleolar organizer region (NOR) silver staining to the promyelocytic leukemia cell line HL-60, before and after dimethylsulfoxide (DMSO) mediated differentiation. The results demonstrated a gradual suppression of rDNA transcription during terminal maturation of these bone-marrow-der...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer genetics and cytogenetics 1984-01, Vol.13 (2), p.159-166
Hauptverfasser:	REEVES, B. R, CASEY, G, HONEYCOMBE, J. R, SMITH, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Cycle - drug effects Cell Differentiation - drug effects Cell Line Dimethyl Sulfoxide - pharmacology Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Nucleolus Organizer Region - ultrastructure Silver Staining and Labeling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have applied nucleolar organizer region (NOR) silver staining to the promyelocytic leukemia cell line HL-60, before and after dimethylsulfoxide (DMSO) mediated differentiation. The results demonstrated a gradual suppression of rDNA transcription during terminal maturation of these bone-marrow-derived cells and support our hypothesis that there are characteristic NOR staining profiles for different bone marrow cell types.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(84)90057-8