Distribution and stability of [ 111In]bleomycin and its fractions in tumor-bearing mice

Distribution and stability of [ 111In]bleomycin and its fractions in tumor-bearing mice

The tissue distributions in glioma-bearing mice given injections of [ 111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [ 111In]BLM-B 2 and -A 2 were higher than those for unfractionated [ 111In]BLM. Autoradiographs of electrophoretic gels o...

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Veröffentlicht in:International journal of nuclear medicine & biology 1984, Vol.11 (2), p.129-139
Hauptverfasser: Hou, De-Yan, Hoch, Hans, Johnston, Gerald S., Tsou, K.C., Farkas, Raymond J., Miller, Elizabeth E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Autoradiography
Bleomycin - metabolism
Brain - metabolism
Brain Neoplasms - diagnostic imaging
Chromatography, Thin Layer
Electrophoresis, Agar Gel
Glioma - diagnostic imaging
Indium
Male
Mice
Mice, Inbred C57BL
Muscles - metabolism
Radioisotopes
Radionuclide Imaging
Tissue Distribution
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Zusammenfassung:The tissue distributions in glioma-bearing mice given injections of [ 111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [ 111In]BLM-B 2 and -A 2 were higher than those for unfractionated [ 111In]BLM. Autoradiographs of electrophoretic gels of urine containing [ 111In]BLM or one of its fractions differed from those containing 111InCl 3 [ 111In]BLM and its fractions (A 2 and B 2) were found to be stable in vivo. The fractions may be more useful in the clinic than [ 111In]BLM.
ISSN:0047-0740
DOI:10.1016/0047-0740(84)90048-2