Oligomycin sensitivity-conferring protein (OSCP) of beef heart mitochondria: Internal sequence homology and structural relationship with other proteins

Structural analysis of oligomycin sensitivity-conferring protein (OSCP) revealed repeating sequences (residues 1-89, 105-190) suggesting an evolution of the protein by gene duplication. In addition to the reported homology with the δ-subunit of Escherichia coli F 1ATPase, OSCP also shows a certain h...

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Veröffentlicht in:	FEBS letters 1984-09, Vol.175 (1), p.109-112
Hauptverfasser:	Ovchinnikov, Yu.A., Modyanov, N.N., Grinkevich, V.A., Aldanova, N.A., Kostetsky, P.V., Trubetskaya, O.E., Hundal, T., Ernster, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - isolation & purification Amino Acid Sequence Animals Carrier Proteins - isolation & purification Cattle Comparative analysis coupling factor 0 coupling factor 1 Escherichia coli F 0F 1 heart homology Macromolecular Substances Membrane Proteins - isolation & purification Mitochondria, Heart - metabolism Mitochondrial ADP, ATP Translocases Oligomycin sensitivity-conferring protein Sequence Software Structural relationship Structure-Activity Relationship Subunit
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Zusammenfassung:	Structural analysis of oligomycin sensitivity-conferring protein (OSCP) revealed repeating sequences (residues 1-89, 105-190) suggesting an evolution of the protein by gene duplication. In addition to the reported homology with the δ-subunit of Escherichia coli F 1ATPase, OSCP also shows a certain homology with the b-subunit of E. coli F 0 and the ADP/ATP carrier of mitochondria.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(84)80580-3