Hemodynamic Effects of Angiotensin and Renin Inhibition in Dogs with Acute Left Ventricular Failure

Hemodynamic Effects of Angiotensin and Renin Inhibition in Dogs with Acute Left Ventricular Failure

The effects of enalaprilat (MK-422), an angiotensin converting enzyme inhibitor, were compared to those of SCRIP, a renin inhibitor, in experimentally induced left ventricular failure. In anesthetized dogs, acute left ventricular failure was induced by repeated embolization, via the left main corona...

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Veröffentlicht in:The American journal of medicine 1984-08, Vol.77 (2), p.7-12
Hauptverfasser: Sweet, Charles S., Ludden, C.T., Frederick, C.M., RIBEIRO, L.G.T.
Format: Artikel
Sprache:eng
Schlagworte:
Angiotensin-Converting Enzyme Inhibitors
Animals
Blood Pressure - drug effects
Cardiac Output - drug effects
Coronary Vessels - drug effects
Dipeptides - therapeutic use
Dogs
Embolism
Enalaprilat
Female
Heart Failure - drug therapy
Heart Rate - drug effects
Hemodynamics - drug effects
Injections, Intravenous
Kidney - drug effects
Male
Oligopeptides - therapeutic use
Renin-Angiotensin System - drug effects
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Zusammenfassung:The effects of enalaprilat (MK-422), an angiotensin converting enzyme inhibitor, were compared to those of SCRIP, a renin inhibitor, in experimentally induced left ventricular failure. In anesthetized dogs, acute left ventricular failure was induced by repeated embolization, via the left main coronary artery, with 50 μm plastic microspheres. Embolization significantly increased left ventricular enddiastolic pressure from 6 ± 1 to 14 ± 1 (p
ISSN:0002-9343
1555-7162
DOI:10.1016/S0002-9343(84)80052-2