Comparison of Quinidine by Fluorescence Polarization Immunoassay and High Pressure Liquid Chromatography

Analysis of quinidine was performed using fluorescence polarization immunoassay (Abbott TDx™) with an ion-pairing adsorption high pressure liquid chromatography (HPLC) technique as the comparative method. Correlation of 110 clinical samples was excellent (r2 = 0.983). TDx calibration appeared stable...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of analytical toxicology 1984-07, Vol.8 (4), p.161-163
Hauptverfasser:	Bridges, Robert R., Smith, Catherine M., Jennison, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Analysis Antibody Specificity Biological and medical sciences Chromatography, High Pressure Liquid - methods Cross Reactions Fluorescence polarization Fluorescent Antibody Technique General pharmacology High-performance liquid chromatography Humans Immunoassays Liquid chromatography Medical sciences Metabolites Pharmacology. Drug treatments Pressure Quinidine Quinidine - blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Analysis of quinidine was performed using fluorescence polarization immunoassay (Abbott TDx™) with an ion-pairing adsorption high pressure liquid chromatography (HPLC) technique as the comparative method. Correlation of 110 clinical samples was excellent (r2 = 0.983). TDx calibration appeared stable for 14 days. There is minimal contribution to the concentration of quinidine due to the presence of metabolite. The TDx method is rapid, precise, and accurate.
ISSN:	0146-4760 1945-2403
DOI:	10.1093/jat/8.4.161