"Original Antigenic Sin" Phenomenon in Experimental Flavivirus Infections of Guinea Pigs: Studies by Enzyme-Linked Immunosorbent Assay

Guinea pigs were sequentially infected with two closely related flavivituses (Japanese encephalitis and West Nile viruses), and their antibody responses were studied both by enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI). The results by ELISA always showed “original a...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 1984, Vol.28(5), pp.569-574
Hauptverfasser:	Inouye, Sakae, Matsuno, Shigeo, Tsurukubo, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral - biosynthesis Antigens, Viral - immunology Arboviral encephalitis Arboviroses Biological and medical sciences Encephalitis Virus, Japanese - immunology Encephalitis, Japanese - immunology Enzyme-Linked Immunosorbent Assay Experimental viral diseases and models Female Flavivirus Flavivirus - immunology Guinea Pigs Hemagglutination Inhibition Tests Human viral diseases Infectious diseases Japanese encephalitis virus Medical sciences Togaviridae Infections - immunology Tropical medicine Tropical viral diseases Viral diseases West Nile Fever - immunology West Nile virus West Nile virus - immunology
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Zusammenfassung:	Guinea pigs were sequentially infected with two closely related flavivituses (Japanese encephalitis and West Nile viruses), and their antibody responses were studied both by enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI). The results by ELISA always showed “original antigenic sin” responses: antibody activity of sera after the second infection was higher to the first infecting virus than to the second infecting virus. However, the results obtained by HI were variable.
ISSN:	0385-5600 1348-0421
DOI:	10.1111/j.1348-0421.1984.tb00709.x