Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found i...

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Veröffentlicht in:Nature (London) 1984-08, Vol.310 (5979), p.650-655
Hauptverfasser: Weiss, Elisabeth H, Golden, Lynn, Fahrner, Karen, Mellor, Andrew L, Devlin, James J, Bullman, Hilary, Tiddens, Harm, Bud, Harriet, Flavell, Richard A
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Sprache:eng
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Zusammenfassung:The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.
ISSN:0028-0836
1476-4687
DOI:10.1038/310650a0