A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers
A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) w...
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| Veröffentlicht in: | The Journal of infectious diseases 1984-08, Vol.150 (2), p.195-201 |
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| container_end_page | 201 |
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| container_issue | 2 |
| container_start_page | 195 |
| container_title | The Journal of infectious diseases |
| container_volume | 150 |
| creator | Meschievitz, C. K. Schultz, S. B. Dick, E. C. |
| description | A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) with donor-hours of exposure. This model can be used to define routes of transmission, to explore methods of controlling dissemination, to study resistance mechanisms, and to test preventive and therapeutic agents. |
| doi_str_mv | 10.1093/infdis/150.2.195 |
| format | Article |
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K.</creatorcontrib><creatorcontrib>Schultz, S. B.</creatorcontrib><creatorcontrib>Dick, E. C.</creatorcontrib><title>A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) with donor-hours of exposure. 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C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-cc222673ad1c6926a31ce67795c7a8c23fd2ac163e54f256ae265879a38a7f943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Common Cold - microbiology</topic><topic>Common Cold - transmission</topic><topic>Disease transmission</topic><topic>Diseases</topic><topic>Experimental infection</topic><topic>Geometric mean</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Mucosa - microbiology</topic><topic>Original Articles</topic><topic>Rhinovirus</topic><topic>Rhinovirus - isolation & purification</topic><topic>Television transmission</topic><topic>Time Factors</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><topic>Viruses</topic><topic>Volunteerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meschievitz, C. K.</creatorcontrib><creatorcontrib>Schultz, S. B.</creatorcontrib><creatorcontrib>Dick, E. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meschievitz, C. K.</au><au>Schultz, S. B.</au><au>Dick, E. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1984-08</date><risdate>1984</risdate><volume>150</volume><issue>2</issue><spage>195</spage><epage>201</epage><pages>195-201</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) with donor-hours of exposure. This model can be used to define routes of transmission, to explore methods of controlling dissemination, to study resistance mechanisms, and to test preventive and therapeutic agents.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>6088646</pmid><doi>10.1093/infdis/150.2.195</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1984-08, Vol.150 (2), p.195-201 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81216178 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adolescent Adult Antibodies Biological and medical sciences Common Cold - microbiology Common Cold - transmission Disease transmission Diseases Experimental infection Geometric mean Human viral diseases Humans Infections Infectious diseases Male Medical sciences Nasal Mucosa - microbiology Original Articles Rhinovirus Rhinovirus - isolation & purification Television transmission Time Factors Viral diseases Viral diseases of the respiratory system and ent viral diseases Viruses Volunteerism |
| title | A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers |
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