A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers

A Model for Obtaining Predictable Natural Transmission of Rhinoviruses in Human Volunteers

A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) w...

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Veröffentlicht in:The Journal of infectious diseases 1984-08, Vol.150 (2), p.195-201
Hauptverfasser: Meschievitz, C. K., Schultz, S. B., Dick, E. C.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antibodies
Biological and medical sciences
Common Cold - microbiology
Common Cold - transmission
Disease transmission
Diseases
Experimental infection
Geometric mean
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Nasal Mucosa - microbiology
Original Articles
Rhinovirus
Rhinovirus - isolation & purification
Television transmission
Time Factors
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
Volunteerism
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Beschreibung
Zusammenfassung:A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P < .01) with donor-hours of exposure. This model can be used to define routes of transmission, to explore methods of controlling dissemination, to study resistance mechanisms, and to test preventive and therapeutic agents.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/150.2.195