Effect of Vehicle Dielectric Properties on Rectal Absorption of Acetaminophen
The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles.
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Veröffentlicht in: | Journal of pharmaceutical sciences 1971-04, Vol.60 (4), p.600-602 |
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container_title | Journal of pharmaceutical sciences |
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creator | Shangraw, Ralph F. Douglas Walkling, W. |
description | The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles. |
doi_str_mv | 10.1002/jps.2600600419 |
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Pharm. Sci</addtitle><description>The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles.</description><subject>Absorption</subject><subject>Acetaminophen - metabolism</subject><subject>Acetaminophen - urine</subject><subject>acetaminophen-effect of vehicle dielectric constant</subject><subject>Acetaminophen-rectal absorption from aqueous suspension</subject><subject>Acetaminophen—rectal absorption from aqueous suspension, propylene glycol suspension, theobroma oil suppository, relationship to dielectric constants</subject><subject>Adult</subject><subject>Biological Transport</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Dielectric constant-role in rectal absorption of acetaminophen in different vehicles</subject><subject>Humans</subject><subject>Male</subject><subject>Pharmaceutical Vehicles</subject><subject>propylene glycol suspension</subject><subject>Propylene Glycols</subject><subject>Rectal absorption</subject><subject>Rectal absorption, acetaminophen—effect of vehicle dielectric constant</subject><subject>Rectum</subject><subject>relationship to dielectric constants</subject><subject>Solubility</subject><subject>Suppositories - analysis</subject><subject>theobroma oil suppository</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAUhYMoOj627oSu3HXMo2na5aDji_H9AjehTW8w2mlq0vHx783QQXEhQiBw7ncO3HMR2iZ4SDCme8-tH9IU4_ASki-hAeEUxykmYhkNAkBjxpN8Da17_4znGOeraJUTmjFBB-hsrDWoLrI6uocno2qIDgzUQXJGRZfOtuA6Az6yTXQd1KKORqW3ru1MUIJrpKArpqax7RM0m2hFF7WHrcW_ge4Ox7f7x_Hk4uhkfzSJVUJFHiesErxUmia0rIiqgIMmCRc5LjQBVvBSl7TSQgFnqWCCqJSJSuRlnmGNs5JtoN0-t3X2dQa-k1PjFdR10YCdeZkRSnhK0wAOe1A5670DLVtnpoX7lATLeX8y9Cd_-guGnUXyrJxC9Y0vCgvzvJ-_mxo-_0mTp5c3v7Lj3mt8Bx_f3sK9yPmWXD6cH8kH-kjY8eFEXgU-63kIVb4ZcNIrA42CyrhwCllZ89caX_Gvngc</recordid><startdate>197104</startdate><enddate>197104</enddate><creator>Shangraw, Ralph F.</creator><creator>Douglas Walkling, W.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197104</creationdate><title>Effect of Vehicle Dielectric Properties on Rectal Absorption of Acetaminophen</title><author>Shangraw, Ralph F. ; Douglas Walkling, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4279-43d75bcf242bd1cde5ef145790af1e3a5bfb2df7ce5367371c637d79b980f08b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Absorption</topic><topic>Acetaminophen - metabolism</topic><topic>Acetaminophen - urine</topic><topic>acetaminophen-effect of vehicle dielectric constant</topic><topic>Acetaminophen-rectal absorption from aqueous suspension</topic><topic>Acetaminophen—rectal absorption from aqueous suspension, propylene glycol suspension, theobroma oil suppository, relationship to dielectric constants</topic><topic>Adult</topic><topic>Biological Transport</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Dielectric constant-role in rectal absorption of acetaminophen in different vehicles</topic><topic>Humans</topic><topic>Male</topic><topic>Pharmaceutical Vehicles</topic><topic>propylene glycol suspension</topic><topic>Propylene Glycols</topic><topic>Rectal absorption</topic><topic>Rectal absorption, acetaminophen—effect of vehicle dielectric constant</topic><topic>Rectum</topic><topic>relationship to dielectric constants</topic><topic>Solubility</topic><topic>Suppositories - analysis</topic><topic>theobroma oil suppository</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shangraw, Ralph F.</creatorcontrib><creatorcontrib>Douglas Walkling, W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shangraw, Ralph F.</au><au>Douglas Walkling, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Vehicle Dielectric Properties on Rectal Absorption of Acetaminophen</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1971-04</date><risdate>1971</risdate><volume>60</volume><issue>4</issue><spage>600</spage><epage>602</epage><pages>600-602</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5128372</pmid><doi>10.1002/jps.2600600419</doi><tpages>3</tpages></addata></record> |
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subjects | Absorption Acetaminophen - metabolism Acetaminophen - urine acetaminophen-effect of vehicle dielectric constant Acetaminophen-rectal absorption from aqueous suspension Acetaminophen—rectal absorption from aqueous suspension, propylene glycol suspension, theobroma oil suppository, relationship to dielectric constants Adult Biological Transport Chemical Phenomena Chemistry Dielectric constant-role in rectal absorption of acetaminophen in different vehicles Humans Male Pharmaceutical Vehicles propylene glycol suspension Propylene Glycols Rectal absorption Rectal absorption, acetaminophen—effect of vehicle dielectric constant Rectum relationship to dielectric constants Solubility Suppositories - analysis theobroma oil suppository Time Factors |
title | Effect of Vehicle Dielectric Properties on Rectal Absorption of Acetaminophen |
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