Effect of Vehicle Dielectric Properties on Rectal Absorption of Acetaminophen

The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1971-04, Vol.60 (4), p.600-602
Hauptverfasser:	Shangraw, Ralph F., Douglas Walkling, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acetaminophen - metabolism Acetaminophen - urine acetaminophen-effect of vehicle dielectric constant Acetaminophen-rectal absorption from aqueous suspension Acetaminophen—rectal absorption from aqueous suspension, propylene glycol suspension, theobroma oil suppository, relationship to dielectric constants Adult Biological Transport Chemical Phenomena Chemistry Dielectric constant-role in rectal absorption of acetaminophen in different vehicles Humans Male Pharmaceutical Vehicles propylene glycol suspension Propylene Glycols Rectal absorption Rectal absorption, acetaminophen—effect of vehicle dielectric constant Rectum relationship to dielectric constants Solubility Suppositories - analysis theobroma oil suppository Time Factors
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Beschreibung
Zusammenfassung:	The rectal absorption of acetaminophen from an aqueous suspension, a propylene glycol suspension, and a theobroma oil suppository was measured by urinary excretion. The results are discussed in terms of their relationship to the dielectric constants of the vehicles.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600600419