Plasma Protein Binding of Warfarin: Methodological Considerations

Recent theoretical work has suggested that radiochemical impurities can significantly alter the binding results for highly protein-bound drugs. We compared protein binding of warfarin by ultrafiltration and equilibrium dialysis with 98% radiochemically pure [14C]warfarin. Ultrafiltration and equilib...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1984-07, Vol.73 (7), p.1000-1001
Hauptverfasser:	Mungall, Dennis, Wong, Yan Yan, Talbert, Robert L., Crawford, Michael H., Marshall, James, Hawkins, David W., Ludden, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Proteins - metabolism Dialysis - methods General pharmacology Humans Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships plasma protein binding plasma protein binding of warfarin Plasma protein binding-methodological considerations Plasma protein binding—methodological considerations, warfarin, radiochemical impurities Protein Binding radiochemical impurities Radiochemical impurities-methodological considerations Radiochemical impurities—methodological considerations, plasma protein binding of warfarin Ultrafiltration - methods warfarin Warfarin - blood Warfarin-methodological considerations Warfarin—methodological considerations, plasma protein binding
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