Delayed Kidney Allograft Function after Simultaneous Pancreas-Kidney Transplantation

Abstract Background Simultaneous pancreas-kidney transplantation (SPKT) is one of the treatments for insulin-dependent chronic renal failure patients. Methods One-year patient and kidney allograft survival rates of 150 patients undergoing SPKT were subjected to Cox regression and Kaplan-Meier analyses. Uni- and multivariate methods identified risk factors involved in allograft and patient survival. Results One-year patient and kidney allograft survival rates were 82% and 80%, respectively. Delayed graft function (DGF) ( P = .001; hazard ratio [HR]5.41) and acute kidney rejection episodes ( P = .016; HR 3.36) were related to 1 year patient survival as well as intra-abdominal infection (IAI) rates. (IAI). One-year kidney allograft survival was related to DGF ( P = .013; odds ratio [OR] 3.39), acute rejection ( P = .001; OR 4.74), and IAI ( P = .003, OR 6.29). DGF was related to a time on dialysis >27 months ( P = .046; OR 2.59), cold kidney ischemia time >14 hours ( P = .027; OR 2.94), donor age >25 years ( P = .03; OR 2.82), and donor serum sodium concentration >155 mEq/L ( P < .0001; OR 1.09). Female kidney to male recipient in 17% of the cases did not increase the risk of DGF. We observed an important correlation between donor serum sodium and creatinine ( P < .0001), which suggested undertreatment of diabetes insipidus secondary to brain death. Conclusions DGF, acute rejection, and IAI were the main determinants of survival after SPKT. Improving the care of deceased donors may reduce DGF occurrence.