Further evidence supporting the association between 5HTR2C gene and bipolar disorder

Abstract Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls ( P = 0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-mo...

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Veröffentlicht in:	Psychiatry research 2010-12, Vol.180 (2), p.151-152
Hauptverfasser:	Mazza, Marianna, Mandelli, Laura, Martinotti, Giovanni, Di Nicola, Marco, Tavian, Daniela, Negri, Gloria, Colombo, Elisa, Missaglia, Sara, De Ronchi, Diana, Colombo, Roberto, Janiri, Luigi, Serretti, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Aged Aged, 80 and over Biological and medical sciences Bipolar disorder Bipolar Disorder - epidemiology Bipolar Disorder - genetics Bipolar disorders Female Gene Frequency Genetic Linkage - genetics Genotype Humans Male Medical sciences Middle Aged Mood disorders Polymorphism, Single Nucleotide Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2C - genetics Serotonin receptor 2C Substance abuse Substance-Related Disorders - epidemiology Substance-Related Disorders - genetics Young Adult
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Zusammenfassung:	Abstract Three 5HTR2C polymorphisms were investigated in bipolar (BD) spectrum disorders. The functional rs6318 G (Cys) allele was more frequent in BD patients than in controls ( P = 0.0036). Thus, 5HTR2C may have a role in BD. Further investigation is required to understand its involvement in co-morbidity for substance use disorders (SUDs).
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2009.12.006