Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs)

N-Arylsulfonyl-based MMPs inhibitors (MMPIs) are among the most prominent inhibitors possessing nanomolar affinity. However, their poor bioavailability remains critical for the drug development of this family of molecules. The structural analysis of the complex of NNGH (the most representative member of the family) with MMP-12 provided us with the basis to effectively design simple NNGH analogues with enhanced solubility in water. Following this approach, the sec-butyl residue, not directly involved in the binding with MMP, has been replaced with hydrophilic residues thus yielding new potent inhibitors soluble in water. Sulfonamidic MMPs inhibitors soluble in water were obtained relying on structural-based approach. This new family of large spectrum, nanomolar inhibitors can be seen as water soluble NNGH analogues. [Display omitted]