Tissue penetration of antibiotics

A novel method of deduction is described for determining the amount of antibiotic present in the tissues at any point in time following intravenous administration of a given dose. Application of this calculation to amoxycillin, carbenicillin, ticar-cillin, nafcillin, dicloxacillin and temocillin indicates that the passage of drug from the vascular compartment to the extravascular fluid is rapid. The results obtained with this method of calculation are discussed in relation to the results obtained by conventional pharmacokinetic analysis and by direct assay of tissue fluid samples.