Synthesis and Selected Pharmacology of Anthranilamides

A series of anthranilamides of diverse structure were prepared by the nucleophilic ring opening of isatoic anhydrides. Sixteen analogs, 10 of them previously unknown in the literature, were submitted to general pharmacologic screening. Several of the compounds displayed CNS depression, anti-inflamma...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1971-05, Vol.60 (5), p.703-707
Hauptverfasser:	Heindel, Ned D., Fives, William P., Lemke, Thomas F., Carrano, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemical synthesis Amides - pharmacology analgesic potential-anthranilamides Analgesics - pharmacology Animals Anthranilamides-synthesis from isatoic anhydrides Anti-inflammatory Anti-Inflammatory Agents - pharmacology Anti-inflammatory, analgesic potential—anthranilamides Antitremor activity-anthranilamides Central Nervous System - drug effects CNS depressant activity-anthranilamides ortho-Aminobenzoates - chemical synthesis ortho-Aminobenzoates - pharmacology Rats Rats, Inbred Strains
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Beschreibung
Zusammenfassung:	A series of anthranilamides of diverse structure were prepared by the nucleophilic ring opening of isatoic anhydrides. Sixteen analogs, 10 of them previously unknown in the literature, were submitted to general pharmacologic screening. Several of the compounds displayed CNS depression, anti-inflammatory-analgesic, and antitremor activities.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600600509