Effects of Age on the Clinical Pharmacokinetics of Ibuprofen

The pharmacokinetics of ibuprofen (Motrin) were studied in 17 normal elderly men and women aged 65 to 78 years. Total and free unbound plasma concentrations of ibuprofen were determined 12 hours after single oral doses of 400, 800, and 1,200 mg. These results were then compared with those of a simil...

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Veröffentlicht in:	The American journal of medicine 1984-07, Vol.77 (1), p.47-50
Hauptverfasser:	Albert, Kenneth S., Gillespie, William R., Wagner, John G., Pau, Alice, Lockwood, G.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Clinical Trials as Topic Dose-Response Relationship, Drug Humans Ibuprofen - administration & dosage Ibuprofen - metabolism Kinetics Male
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Zusammenfassung:	The pharmacokinetics of ibuprofen (Motrin) were studied in 17 normal elderly men and women aged 65 to 78 years. Total and free unbound plasma concentrations of ibuprofen were determined 12 hours after single oral doses of 400, 800, and 1,200 mg. These results were then compared with those of a similar study involvihg 15 normal young men 22 to 35 years old. The two age groups showed no statistically significant dlfferences in any pharmacokinetic parameter studied. Therefore, accordlng to thls study, advanced age has only minimal influence on the pharmacokinetics of ibuprofen, and dosage apparently does not need to be adjusted for age.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/S0002-9343(84)80018-2