Hypoglycemic Activity of Aldose Reductase Inhibitor, 1-[(p-Bromophenyl) sulfonyl] hydantoin

The hypoglycemic activity of a potent aldose reductase inhibitor, 1-[(p-bromophenyl)-sulfonyl] hydantoin (p-Br-PSH), was tested. The compound was not effective when orally administered to rabbits at a dose of 25 mg/kg, whereas statistically significant hypoglycemic activity was observed at doses of...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1984/05/25, Vol.32(5), pp.2030-2032
Hauptverfasser:	MIWA, ICHITOMO, INAGAKI, KAZUHIRO, YASHIRO, TAMOTSU, OKUDA, JUN
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Animals Biological and medical sciences Blood Glucose - metabolism General and cellular metabolism. Vitamins Hydantoins - pharmacology Hypoglycemic Agents - pharmacology Insulin - blood Male Medical sciences Pharmacology. Drug treatments Rabbits Sugar Alcohol Dehydrogenases - antagonists & inhibitors tolbutamide
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Zusammenfassung:	The hypoglycemic activity of a potent aldose reductase inhibitor, 1-[(p-bromophenyl)-sulfonyl] hydantoin (p-Br-PSH), was tested. The compound was not effective when orally administered to rabbits at a dose of 25 mg/kg, whereas statistically significant hypoglycemic activity was observed at doses of 50 and 100 mg/kg. The hypoglycemic activity of p-Br-PSH, however, was lower than that of tolbutamide.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.32.2030