A monoclonal antibody detecting a new human T cell antigen, HuLy-M2

HuLy-m2 is a new T cell antigen detected by a monoclonal antibody. The antibody (anti-HuLy-m2) reacts with 85% of human T cells, 20% B cells, and 50% null cells in peripheral blood. The antibody is cytotoxic, binds protein A, and is of the IgG2a subclass. HuLy-m2 antigen consists of a glycoprotein d...

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Veröffentlicht in:	Transplantation 1984-08, Vol.38 (2), p.143-147
Hauptverfasser:	THURLOW, P. J, ERIN LOVERING, K, MCKENZIE, I. F. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Monoclonal - immunology Antilymphocyte Serum - immunology Biological and medical sciences Cytotoxicity, Immunologic Electrophoresis, Polyacrylamide Gel Epitopes - analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins - analysis Humans Immunobiology Immunoglobulin G - analysis Macaca Molecular Weight N-Acetylneuraminic Acid Organs and cells involved in the immune response Sialic Acids - analysis Staphylococcal Protein A - metabolism T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	HuLy-m2 is a new T cell antigen detected by a monoclonal antibody. The antibody (anti-HuLy-m2) reacts with 85% of human T cells, 20% B cells, and 50% null cells in peripheral blood. The antibody is cytotoxic, binds protein A, and is of the IgG2a subclass. HuLy-m2 antigen consists of a glycoprotein dimer Mr 37,000 subunit structure, in which sialic acid and carbohydrate play some role in antigenicity. Capping studies showed the HuLy-m2 antigen to be distinct from the previously described OKT-3, 4, 8, HuLy-m1 (OKT11), and HuLy-m3 antigens.
ISSN:	0041-1337 1534-6080
DOI:	10.1097/00007890-198408000-00010