Effect of isoprenaline on cells in different phases of the mitotic cycle

The effects of isoprenaline on parotid acinar cells in different phases of the mitotic cycle have been investigated. Cells in mitosis at the time of drug administration are not depleted of secretory granules whilst those in other phases are. The drug causes temporary blocks both in metaphase and in...

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Veröffentlicht in:	Experimental cell research 1971-11, Vol.69 (1), p.148-160
Hauptverfasser:	Radley, J.M., Hodgson, G.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Autoradiography Cell Nucleus - metabolism Cells - drug effects Cytoplasmic Granules - drug effects DNA - biosynthesis Female Histocytochemistry Hyperplasia - chemically induced Injections, Intraperitoneal Iodine Isotopes Isoproterenol - pharmacology Male Methods Mice Mice, Inbred Strains Microscopy, Electron Mitosis - drug effects Parotid Gland - cytology Propranolol - pharmacology Rats Rats, Inbred Strains Submandibular Gland - cytology Thymidine - metabolism Time Factors Tritium Uridine - metabolism
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Zusammenfassung:	The effects of isoprenaline on parotid acinar cells in different phases of the mitotic cycle have been investigated. Cells in mitosis at the time of drug administration are not depleted of secretory granules whilst those in other phases are. The drug causes temporary blocks both in metaphase and in the G2 phase. The blocks are prolonged by repeated injections of the drug. Cells continue to undergo DNA synthesis during the period of secretion following the drug. The mitotic delay appears to be specific for the parotid and submaxillary glands.
ISSN:	0014-4827 1090-2422
DOI:	10.1016/0014-4827(71)90320-X