The effects of NaCl on the amino acid acceptor activity of rat liver tRNA

The effects of NaCl on the amino acid acceptor activity of rat liver tRNA was studied, and it was established that NaCl causes alterations of the acceptor activities for valine, lysine, leucine, and phenylalanine. Both the rate and the final level of the esterification of valine to tRNA was altered...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1971-07, Vol.145 (1), p.164-168
Hauptverfasser:	Sein, K.T., Bećarević, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Amino Acyl-tRNA Synthetases - antagonists & inhibitors Amino Acyl-tRNA Synthetases - isolation & purification Animals Carbon Isotopes Chromatography Chromatography, DEAE-Cellulose Kinetics Leucine - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Lysine - metabolism Male Methylation Phenylalanine - metabolism Phosphates - pharmacology Rats Rats, Inbred Strains RNA, Transfer - metabolism Serum Albumin Silicon Dioxide Sodium - pharmacology Sodium Chloride - pharmacology Tritium Valine - metabolism
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Beschreibung
Zusammenfassung:	The effects of NaCl on the amino acid acceptor activity of rat liver tRNA was studied, and it was established that NaCl causes alterations of the acceptor activities for valine, lysine, leucine, and phenylalanine. Both the rate and the final level of the esterification of valine to tRNA was altered by NaCl. Formation of valyl-tRNA is more sensitive to NaH 2PO 4 than to the same molarity of NaCl. It was also found that valyl-tRNA synthesis is more sensitive to 0.3 m NaCl when a partially purified enzyme was used.
ISSN:	0003-9861 1096-0384
DOI:	10.1016/0003-9861(71)90023-3