Polymorphism of Human Constitutive Heterochromatin
Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visua...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1971-11, Vol.174 (4010), p.702-704 |
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| container_issue | 4010 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Craig-Holmes, Ann P. Shaw, Margery W. |
| description | Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population. |
| doi_str_mv | 10.1126/science.174.4010.702 |
| format | Article |
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A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.174.4010.702</identifier><identifier>PMID: 5123418</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Cell nucleus ; Chromatin ; Chromosome morphology ; Chromosomes ; Chromosomes, Human, 1-3 ; Chromosomes, Human, 13-15 ; Chromosomes, Human, 16-18 ; Chromosomes, Human, 19-20 ; Chromosomes, Human, 21-22 and Y ; Chromosomes, Human, 6-12 and X ; Crossovers ; Cultured cells ; DNA ; Herpesviridae ; Heterochromatin ; Human herpesvirus 2 ; Humans ; Lymphocytes ; Methods ; Nucleic Acid Denaturation ; Nucleic Acid Renaturation ; Polymorphism, Genetic</subject><ispartof>Science (American Association for the Advancement of Science), 1971-11, Vol.174 (4010), p.702-704</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-2f9a0297cafcd7ce19dc30a312c17d14e9b34cd9bfb4b8d664eb0cbc0cd18bf23</citedby><cites>FETCH-LOGICAL-c448t-2f9a0297cafcd7ce19dc30a312c17d14e9b34cd9bfb4b8d664eb0cbc0cd18bf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1733758$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1733758$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5123418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Craig-Holmes, Ann P.</creatorcontrib><creatorcontrib>Shaw, Margery W.</creatorcontrib><title>Polymorphism of Human Constitutive Heterochromatin</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.</description><subject>Cell nucleus</subject><subject>Chromatin</subject><subject>Chromosome morphology</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, 1-3</subject><subject>Chromosomes, Human, 13-15</subject><subject>Chromosomes, Human, 16-18</subject><subject>Chromosomes, Human, 19-20</subject><subject>Chromosomes, Human, 21-22 and Y</subject><subject>Chromosomes, Human, 6-12 and X</subject><subject>Crossovers</subject><subject>Cultured cells</subject><subject>DNA</subject><subject>Herpesviridae</subject><subject>Heterochromatin</subject><subject>Human herpesvirus 2</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Methods</subject><subject>Nucleic Acid Denaturation</subject><subject>Nucleic Acid Renaturation</subject><subject>Polymorphism, Genetic</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LwzAYx4Moc06_wYSevHU-eWnTHGWoEwZ60HNI0pR1tM1MUmHf3owVPT3wf3vgh9ASwwpjUj4G09rB2BXmbMUgqRzIBZpjEEUuCNBLNAegZV4BL67RTQh7gOQJOkOzAhPKcDVH5MN1x975w64NfeaabDP2asjWbgixjWNsf2y2sdF6Z3be9Sq2wy26alQX7N10F-jr5flzvcm3769v66dtbhirYk4aoYAIblRjam4sFrWhoCgmBvMaMys0ZaYWutFMV3VZMqvBaAOmxpVuCF2gh_Puwbvv0YYo-zYY23VqsG4MssKY07KoUpCdg8a7ELxt5MG3vfJHiUGeUMkJlUyo5AmVTKhS7X7aH3Vv67_SxCb5y7O_D9H5_01OKU9ffwG6bHE7</recordid><startdate>19711112</startdate><enddate>19711112</enddate><creator>Craig-Holmes, Ann P.</creator><creator>Shaw, Margery W.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19711112</creationdate><title>Polymorphism of Human Constitutive Heterochromatin</title><author>Craig-Holmes, Ann P. ; Shaw, Margery W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-2f9a0297cafcd7ce19dc30a312c17d14e9b34cd9bfb4b8d664eb0cbc0cd18bf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Cell nucleus</topic><topic>Chromatin</topic><topic>Chromosome morphology</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, 1-3</topic><topic>Chromosomes, Human, 13-15</topic><topic>Chromosomes, Human, 16-18</topic><topic>Chromosomes, Human, 19-20</topic><topic>Chromosomes, Human, 21-22 and Y</topic><topic>Chromosomes, Human, 6-12 and X</topic><topic>Crossovers</topic><topic>Cultured cells</topic><topic>DNA</topic><topic>Herpesviridae</topic><topic>Heterochromatin</topic><topic>Human herpesvirus 2</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Methods</topic><topic>Nucleic Acid Denaturation</topic><topic>Nucleic Acid Renaturation</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craig-Holmes, Ann P.</creatorcontrib><creatorcontrib>Shaw, Margery W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craig-Holmes, Ann P.</au><au>Shaw, Margery W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of Human Constitutive Heterochromatin</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1971-11-12</date><risdate>1971</risdate><volume>174</volume><issue>4010</issue><spage>702</spage><epage>704</epage><pages>702-704</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5123418</pmid><doi>10.1126/science.174.4010.702</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1971-11, Vol.174 (4010), p.702-704 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Cell nucleus Chromatin Chromosome morphology Chromosomes Chromosomes, Human, 1-3 Chromosomes, Human, 13-15 Chromosomes, Human, 16-18 Chromosomes, Human, 19-20 Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Crossovers Cultured cells DNA Herpesviridae Heterochromatin Human herpesvirus 2 Humans Lymphocytes Methods Nucleic Acid Denaturation Nucleic Acid Renaturation Polymorphism, Genetic |
| title | Polymorphism of Human Constitutive Heterochromatin |
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