A familial paracentric inversion: a short review of the current status

A familial paracentric inversion: a short review of the current status

We present here a familial case of a paracentric inversion in man with a short review of the literature. A paracentric inversion of chromosome 10(q11q26) was found in the amniocytes drawn for advanced maternal age. The presence of the inversion was investigated in 35 family members in three generati...

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Veröffentlicht in:Human genetics 1984-01, Vol.67 (2), p.121-125
Hauptverfasser: VENTER, P. A, DAWSON, B, DU TOIT, J. L, SMITH, E. L, KRITZINGER, N, LANDMAN, A. S, CRONJE, A. S, OPT HOF, J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Chromosome aberrations
Chromosome Banding
Chromosome Inversion
Chromosomes, Human, 6-12 and X
Female
Genetic Carrier Screening
Genetic Counseling
Hepatolenticular Degeneration - genetics
Humans
Male
Maternal Age
Medical genetics
Medical sciences
Pedigree
Pregnancy
Recombination, Genetic
Risk
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Zusammenfassung:We present here a familial case of a paracentric inversion in man with a short review of the literature. A paracentric inversion of chromosome 10(q11q26) was found in the amniocytes drawn for advanced maternal age. The presence of the inversion was investigated in 35 family members in three generations. No recombinants were recognized. The significance of these data for appropriate genetic counselling and possible reproductive risks is discussed.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00272985